MendeLIMS is a laboratory information management system (LIMS) that is adaptable to continuously evolving experimental protocols and sequencing technologies. Large clinical genomics studies require the ability to select from a large population of patients/samples to identify the samples of interest. Samples must be accurately tracked through various transformations in order to be certain that DNA sequencing results are attributable to the correct originating sample. This web-based LIMS has a flexible configuration, is easily implemented with open source tools and can be tooled for large scale management of next generation DNA sequencing platforms.